LTI lab, Monash School of Medicine

TrustAGI lab, Griffith University

Paula Fox Melanoma and Cancer Center

03 PUBLICATIONS

Our Research

Our team publishes cutting-edge research in the fields of artificial intelligence, computational biology, and drug discovery. Below you'll find our latest peer-reviewed publications.

2025

A Review Paper on AI-Driven Protein Design (AIP)

Koh, H.Y.*, Zheng, Y. et al.*

Nature Reviews Bioengineering (2025)

Stay tuned for details
2025

Large language models for scientific discovery in molecular property prediction

Zheng, Y.*, Koh, H.Y.*, Ju, J. et al.*

Nature Machine Intelligence 7, 437–447 (2025)

DOI: https://doi.org/10.1038/s42256-025-00994-z

Abstract

Recent advances in large language models have demonstrated remarkable capabilities in various domains, including natural language processing and code generation. In this work, we extend these capabilities to molecular property prediction, a critical task in drug discovery. We propose a novel approach that leverages the knowledge embedded within large language models to enhance the prediction of molecular properties, leading to more accurate and interpretable results compared to traditional methods.

2024

Physicochemical graph neural network for learning protein–ligand interaction fingerprints from sequence data

Koh, H.Y., Nguyen, A.T.N., Pan, S. et al.

Nature Machine Intelligence 6, 673–687 (2024)

DOI: https://doi.org/10.1038/s42256-024-00847-1

Abstract

Understanding protein-ligand interactions is fundamental to drug discovery and development. We present a novel physicochemical graph neural network architecture designed to learn protein-ligand interaction fingerprints directly from sequence data. Our approach integrates physicochemical properties of amino acids and small molecules to create more informative representations, leading to improved prediction accuracy and interpretability of binding interactions.